The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

 Names of Reporting Persons.

 Perceptive Advisors LLC

 Check the Appropriate Box if a Member of a Group (See Instructions)

 (a) ☐  (b) ☒

 SEC Use Only

 Source of Funds (See Instructions)

 AF

 Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

 ☐

 Citizenship or Place of Organization

 Delaware

Number of

Shares  Beneficially 

Owned by

Each

Reporting

Person

With

 Sole Voting Power

 0

 Shared Voting Power

 6,485,420 (see Item 5)

 Sole Dispositive Power

 0

 Shared Dispositive Power

 6,485,420 (see Item 5)

 Aggregate Amount Beneficially Owned by Each Reporting Person

 6,485,420 (see Item 5)

 Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

 ☐

 Percent of Class Represented by Amount in Row (11)

 11.5% (see Item 5)

 Type of Reporting Person (See Instructions)

 IA

 Names of Reporting Persons.

 Joseph Edelman

 Check the Appropriate Box if a Member of a Group (See Instructions)

 (a) ☐  (b) ☒

 SEC Use Only

 Source of Funds (See Instructions)

 AF

 Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

 ☐

 Citizenship or Place of Organization

 United States of America

Number of

Shares  Beneficially 

Owned by

Each

Reporting

Person

With

 Sole Voting Power

 0

 Shared Voting Power

 6,485,420 (see Item 5)

 Sole Dispositive Power

 0

 Shared Dispositive Power

 6,485,420 (see Item 5)

 Aggregate Amount Beneficially Owned by Each Reporting Person

 6,485,420 (see Item 5)

 Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

 ☐

 Percent of Class Represented by Amount in Row (11)

 11.5% (see Item 5)

 Type of Reporting Person (See Instructions)

 IN

 Names of Reporting Persons.

 Perceptive Life Sciences Master Fund, Ltd.

 Check the Appropriate Box if a Member of a Group (See Instructions)

 (a) ☐  (b) ☒

 SEC Use Only

 Source of Funds (See Instructions)

 WC

 Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

 ☐

 Citizenship or Place of Organization

 Cayman Islands

Number of

Shares  Beneficially 

Owned by

Each

Reporting

Person

With

 Sole Voting Power

 0

 Shared Voting Power

 4,873,721 (see Item 5)

 Sole Dispositive Power

 0

 Shared Dispositive Power

 4,873,721 (see Item 5)

 Aggregate Amount Beneficially Owned by Each Reporting Person

 4,873,721 (see Item 5)

 Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

 ☐

 Percent of Class Represented by Amount in Row (11)

 8.6% (see Item 5)

 Type of Reporting Person (See Instructions)

 CO

 Names of Reporting Persons.

 Perceptive Xontogeny Venture Fund, L.P.

 Check the Appropriate Box if a Member of a Group (See Instructions)

 (a) ☐  (b) ☒

 SEC Use Only

 Source of Funds (See Instructions)

 WC

 Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

 ☐

 Citizenship or Place of Organization

 Delaware

Number of

Shares  Beneficially 

Owned by

Each

Reporting

Person

With

 Sole Voting Power

 0

 Shared Voting Power

 1,611,699 (see Item 5)

 Sole Dispositive Power

 0

 Shared Dispositive Power

 1,611,699 (see Item 5)

 Aggregate Amount Beneficially Owned by Each Reporting Person

 1,611,699 (see Item 5)

 Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

 ☐

 Percent of Class Represented by Amount in Row (11)

 2.9% (see Item 5)

 Type of Reporting Person (See Instructions)

 PN

This Amendment No. 5 to the Schedule 13D is being filed by Perceptive Advisors LLC (“Perceptive Advisors”), Joseph Edelman (“Mr. Edelman”), Perceptive Life Sciences Master Fund, Ltd. (the “Master Fund”), and Perceptive Xontogeny Venture Fund, L.P. (“Perceptive Xontogeny”, and together with Perceptive Advisors, Mr. Edelman, the Master Fund, each of the foregoing, a “Reporting Person,” and collectively, the “Reporting Persons”). Perceptive Xontogeny Ventures GP, LLC (“GP”) is the general partner of Perceptive Xontogeny. Perceptive Advisors serves as the investment advisor to the Master Fund and Perceptive Xontogeny, and Mr. Edelman is the managing member of Perceptive Advisors and GP. The agreement among the Reporting Persons to file this Schedule 13D jointly in accordance with Rule 13d-1(k) of the Securities Exchange Act of 1934, as amended, is attached hereto as Exhibit 1.

The address of the principal business office of each of the Reporting Persons is 51 Astor Place 10th Floor, New York, NY 10003.

The principal business of Perceptive Advisors is managing funds in connection with purchasing, holding and selling securities for investment purposes. The principal business of the Master Fund, and Perceptive Xontogeny is to invest in securities. The principal occupation of Mr. Edelman is as the managing member of Perceptive Advisors.

During the last five years, none of the Reporting Persons, nor to the Reporting Persons’ knowledge, any of the persons listed on Schedule A, has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).

During the last five years, none of the Reporting Persons, nor to the Reporting Persons’ knowledge, any of the persons listed on Schedule A, has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws, other than the previously announced settlement order entered into by Perceptive Advisors with the Securities and Exchange Commission dated September 6, 2022 (File No. 3-21031).

Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Perceptive Xontogeny is a Delaware limited partnership.

The information set forth in rows 11 and 13 of the cover pages to this Schedule 13D is incorporated by reference. The percentage set forth in row 13 is based on 56,425,282 shares of Common Stock to be outstanding, as reported by the Issuer in the Issuer’s Quarterly Report on Form 10-Q filed with the SEC on August 12, 2024.

The information set forth in rows 7 through 10 of the cover pages to this Schedule 13D is incorporated by reference.

4,873,721 shares of the Issuer’s Common Stock;

1,535,155 common warrants (“Warrants,” with each Warrant exercisable for 0.75 shares of Common Stock at an exercise price of $8.025 per share) of the Issuer exercisable for 1,151,366 shares of the Issuer’s Common Stock;

921,093 pre-funded warrants (“Pre-funded Warrants”) of the Issuer exercisable for 921,093 shares of the Issuer’s Common Stock; and

4,070.65 shares of Series X Convertible Preferred Stock, convertible into 678,455.24 shares of Common Stock.

1,611,699 shares of the Issuer’s Common Stock;

460,546 Warrants of the Issuer exercisable for 345,409 shares of the Issuer’s Common Stock; and

25,946.63 shares of Series X Convertible Preferred Stock, convertible into 4,324,524.82 shares of Common Stock.

Name: Joseph Edelman

Title: Managing Member

JOSEPH EDELMAN

By:

Perceptive Advisors LLC

Name: Joseph Edelman

Title: Managing Member

By:

Perceptive Xontogeny Ventures GP, LLC

Name: Joseph Edelman

Title: Managing Member

Master Fund

Name and Citizenship

Position

Principal Business Address

Beneficial
Ownership of

Ordinary
Shares

Scott Dakers

(United Kingdom)

c/o Elian Fiduciary Services (Cayman) Limited

190 Elgin Avenue, George Town

Grand Cayman KY1-9007

Cayman Islands

Ernest A. Morrison

(United Kingdom)

Cox Hallett Wilkinson

Milner House

18 Parliament Street

P.O. Box HM 1561

Hamilton HM FX

Bermuda

James Nicholas

(United States)

c/o GenesisPoint LLC

30 Old Kings Highway S

Darien, CT 06820

Name: Joseph Edelman

Title: Managing Member

JOSEPH EDELMAN

By:

Perceptive Advisors LLC

Name: Joseph Edelman

Title: Managing Member

By:

Perceptive Xontogeny Ventures GP, LLC

Name: Joseph Edelman

Title: Managing Member