00100 - Statement - Condensed Consolidated Balance Sheets
link:presentationLink
link:calculationLink
link:definitionLink
00200 - Statement - Condensed Consolidated Statements of Operations
link:presentationLink
link:calculationLink
link:definitionLink
00300 - Statement - Condensed Consolidated Statements of Comprehensive Loss
link:presentationLink
link:calculationLink
link:definitionLink
00400 - Statement - Condensed Consolidated Statements of Cash Flows
link:presentationLink
link:calculationLink
link:definitionLink
40301 - Disclosure - Financial Instruments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40401 - Disclosure - Available-for-Sale Securities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40501 - Disclosure - Accrued Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40602 - Disclosure - Notes Payable - Maturities of Long-Term Debt (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40603 - Disclosure - Notes Payable - Maturities of Long-Term Debt (Details) (Calc2)
link:presentationLink
link:calculationLink
link:definitionLink
40701 - Disclosure - Commitments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
00090 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
00105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
10101 - Disclosure - Organization and Operations
link:presentationLink
link:calculationLink
link:definitionLink
10201 - Disclosure - Summary of Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
10301 - Disclosure - Financial Instruments
link:presentationLink
link:calculationLink
link:definitionLink
10401 - Disclosure - Available-for-Sale Securities
link:presentationLink
link:calculationLink
link:definitionLink
10501 - Disclosure - Accrued Expenses
link:presentationLink
link:calculationLink
link:definitionLink
10601 - Disclosure - Notes Payable
link:presentationLink
link:calculationLink
link:definitionLink
10701 - Disclosure - Commitments
link:presentationLink
link:calculationLink
link:definitionLink
10801 - Disclosure - Convertible Preferred Stock
link:presentationLink
link:calculationLink
link:definitionLink
10901 - Disclosure - Common Stock Reserved for Future Issuance
link:presentationLink
link:calculationLink
link:definitionLink
11001 - Disclosure - Stock Incentive Plans
link:presentationLink
link:calculationLink
link:definitionLink
20202 - Disclosure - Summary of Significant Accounting Polices (Polices)
link:presentationLink
link:calculationLink
link:definitionLink
30203 - Disclosure - Summary of Significant Accounting Policies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30303 - Disclosure - Financial Instruments (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30403 - Disclosure - Availalbe-for-Sale Secusrities (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30503 - Disclosure - Accrued Expenses (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30603 - Disclosure - Notes Payable (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30703 - Disclosure - Commitments (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
30903 - Disclosure - Common Stock Reserved for Future Issuance (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
31003 - Disclosure - Stock Incentive Plans (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
40101 - Disclosure - Organization and Operations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40201 - Disclosure - Summary of Significant Accounting Policies - Share-based Compensation (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40202 - Disclosure - Summary of Significant Accounting Policies - Net Loss Per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40203 - Disclosure - Summary of Significant Accounting Policies - Deferred Financing Costs (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40601 - Disclosure - Notes Payable - Lines of Credit and Debt Instruments (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40801 - Disclosure - Convertible Preferred Stock (Details)
link:presentationLink
link:calculationLink
link:definitionLink
40901 - Disclosure - Common Stock Reserved for Future Issuance (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41001 - Disclosure - Stock Incentive Plans - Plan Information and Valuation Assumptions (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41002 - Disclosure - Stock Incentive Plans - Stock Option Plan Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
41003 - Disclosure - Stock Incentive Plans - Employee Stock Purchase Plan (Details)
link:presentationLink
link:calculationLink
link:definitionLink