00100 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 00200 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 00300 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 00400 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 40501 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 40602 - Disclosure - Notes Payable - Maturities of Long-Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Commitments (Details) link:presentationLink link:calculationLink link:definitionLink 00090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 00105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 10101 - Disclosure - Organization and Operations link:presentationLink link:calculationLink link:definitionLink 10201 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 10301 - Disclosure - Financial Instruments link:presentationLink link:calculationLink link:definitionLink 10401 - Disclosure - Available-for-Sale Securities link:presentationLink link:calculationLink link:definitionLink 10501 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 10601 - Disclosure - Notes Payable link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Commitments link:presentationLink link:calculationLink link:definitionLink 10801 - Disclosure - Convertible Preferred Stock link:presentationLink link:calculationLink link:definitionLink 10901 - Disclosure - Common Stock Reserved for Future Issuance link:presentationLink link:calculationLink link:definitionLink 11001 - Disclosure - Stock Incentive Plans link:presentationLink link:calculationLink link:definitionLink 20202 - Disclosure - Summary of Significant Accounting Polices (Polices) link:presentationLink link:calculationLink link:definitionLink 30203 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 30303 - Disclosure - Financial Instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 30403 - Disclosure - Availalbe-for-Sale Secusrities (Tables) link:presentationLink link:calculationLink link:definitionLink 30503 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 30603 - Disclosure - Notes Payable (Tables) link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Commitments (Tables) link:presentationLink link:calculationLink link:definitionLink 30903 - Disclosure - Common Stock Reserved for Future Issuance (Tables) link:presentationLink link:calculationLink link:definitionLink 31003 - Disclosure - Stock Incentive Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 40101 - Disclosure - Organization and Operations (Details) link:presentationLink link:calculationLink link:definitionLink 40201 - Disclosure - Summary of Significant Accounting Policies - Share-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 40202 - Disclosure - Summary of Significant Accounting Policies - Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 40203 - Disclosure - Summary of Significant Accounting Policies - Recent Accounting Pronouncements (Details) link:presentationLink link:calculationLink link:definitionLink 40301 - Disclosure - Financial Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 40401 - Disclosure - Available-for-Sale Securities (Details) link:presentationLink link:calculationLink link:definitionLink 40601 - Disclosure - Notes Payable - Lines of Credit and Debt Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 40801 - Disclosure - Convertible Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - Common Stock Reserved for Future Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 41001 - Disclosure - Stock Incentive Plans - Plan Information and Valuation Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 41002 - Disclosure - Stock Incentive Plans - Stock Option Plan Activity (Details) link:presentationLink link:calculationLink link:definitionLink 41003 - Disclosure - Stock Incentive Plans - Compensation Expenses (Details) link:presentationLink link:calculationLink link:definitionLink